yemenjmedYemen Journal of MedicinecoVolume 3 Issue 2MultidisciplinaryEnglishMay-August 2024NNY20240911ArticleClosing the gap: Navigating the percutaneous path for a 2-month-old infant's perimembranous ventricular septal defectEnglishY156159KalyanMunde1EnglishNAnantMunde1EnglishYMohan Paliwal1EnglishY10.18231/j.yjom.2024.013Ventricular septal defects (VSDs) represent a substantial portion of congenital heart diseases, with perimembranous VSD (pmVSD) being the most prevalent variant. While surgical closure is conventional, it carries risks such as atrioventricular block, infection, and neurological issues. In contrast, catheter-based interventions have shown promise, particularly for muscular VSDs, but data for pmVSD closure remains limited. We present a case of a 2-month-old male infant referred for heart failure symptoms, characterized by a grade 3/6 pan systolic murmur and mild cardiomegaly on chest X-ray. Echocardiography revealed a 5.5 mm pmVSD with a peak gradient of 32 mm of Hg and pulmonary artery systolic pressure of 10 mm of Hg. Despite de-congestive therapy, the patient showed no symptomatic improvement, prompting consideration of percutaneous device closure due to the infant's low body weight (3 kg) and failure to thrive.This case report discusses the successful percutaneous closure of a perimembranous ventricular septal defect (pmVSD) in the youngest patient ever recorded. It highlights the effectiveness of transcatheter techniques in managing congenital heart defects in young patients.EnglishPerimembranous VSD, Device closure, Pediatric intervention, Congenital heart disease, Heart failurehttps://yemenjmed.com/admin/abstract?id=118References16191. Aguilar NE, Lopez E. Ventricular septal defects. Bol Asoc Med . 2009;101(4):23and;ndash;32.2. Shah JH, Saraiya SP, Nikam TS, Jha MJ. Transcatheter Device Closure of Perimembranous Ventricular Septal Defect in Pediatric Patients: Long-Term Outcomes. Heart Views. 2020;21(1):17and;ndash;21.3. Lock JE, Block PC, Mckay RG, Baim DS, Keane JF. Transcatheter closure of ventricular septal defects. Circulation. 1988;78(2):361and;ndash;9.4. Narın N, Pamukcu O, Sunkak S, Uzum K, Baykan A. Percutaneous VSDclosure of a baby weighed 3kg. Int J Cardiovasc Acad. 2017;3(1):26and;ndash;8.5. Holzer R, Balzer D, Cao Q, Lock K, Hijazi Z. Device closure of muscular ventricular septal defects using the Amplatzer muscular ventricular septal defect occluder: Immediate and mid-term results of a U.S. Registry. J Am Coll Cardiol. 2004;43(7):1257and;ndash;63.6. Zartner P, Christians C, Stelter JC, Hraand;scaron;ka V, Schneider MB. Transvascular closure of single and multiple muscular ventricular septal defects in neonates and infants b20 kg. Catheter Cardiovasc Interv. 2014;83(4):564and;ndash;70.7. Walavalkar V, Maiya S, Pujar S, Ramachandra P, Siddaiah S, Spronck B. Percutaneous device closure of congenital isolated ventricular septal defects: a single-center retrospective database study amongst 412 cases. Pediatr Cardiol. 2020;41(3):591and;ndash;8.8. Jiang D, Han B, Zhao L, Yingchun Y, Zhang J, Fan Y. Transcatheter Device Closure of Perimembranous and Intracristal Ventricular Septal Defects in Children: Medium- and Long-Term Results. J Am Heart Assoc. 2021;10(11):e020417.