yemenjmedYemen Journal of MedicinecoVolume 3 Issue 2MultidisciplinaryEnglishMay-August 2024NNY20240911ArticleFrusemide-induced acute pancreatitis: Report of a rare caseEnglishY163165Sumaira Kanwal Rafiqui1EnglishNMohamed ElmudathirOsman2EnglishY10.18231/j.yjom.2024.015This paper reported a rare case of frusemide-induced acute pancreatitis in a 65-year-old female who presented to the emergency department with severe epigastric pain and vomiting for two days. Her medical history included type 2 diabetes mellitus and liver cirrhosis caused by hepatitis C virus infection, for which she was taking insulin and spironolactone. Ten days prior, she was prescribed frusemide for poorly controlled ascites. She had no history of alcoholism or gallbladder disease. However, two years ago, the patient developed acute pancreatitis. Upon reviewing her medical record, we found that her first acute pancreatitis episode occurred after she had been prescribed frusemide 40 mg daily for ascites control six days before the pancreatitis episode. Serum amylase was 1022 IU/L, and lipase was 3122 IU/L, while abdominal ultrasonography showed a contracted gallbladder without lithiasis and a normal biliary tree and liver. The patient was diagnosed with frusemide-induced acute pancreatitis. She received conservative management with analgesia, hydration, and fasting. Abdominal paracentesis was performed with an albumin replacement. In the following days, the patient remained stable and afebrile, and her symptoms improved. Consequently, she was discharged with strict instructions to avoid frusemide in the future.EnglishFrusemide, Acute pancreatitis, Rechallenge, Liver cirrhosishttps://yemenjmed.com/admin/abstract?id=120References16191. Munoz A, Katerndahl DA. Diagnosis and management of acute pancreatitis. Am Fam Phys. 2000;62(1):164and;ndash;74.2. Khan FY, Sulaiman TO, Nair AP. Coronavirus disease-19-associated acute pancreatitis: Report of three cases and review of case reports. Open Access Maced. J Med Sci. 2021;9(C):63and;ndash;72.3. Jones MR, Hall OM, Kaye AM, Kaye AD. Drug-induced acute pancreatitis: A review. Ochsner J. 2015;15(1):45and;ndash;51.4. Badalov N, Baradarian R, Iswara K, Steinberg W, Tenner S. Druginduced acute pancreatitis: An evidence-based review. Clin Gastro Hepatol. 2007;5(6):648and;ndash;61.5. Chao CT, Chao JY. Case report: Furosemide and pancreatitis: Importance of dose and latency period before reaction. Can Fam Physician. 2013;59(1):43and;ndash;8.6. Jones PE, Oelbaum MH. Frusemide-induced pancreatitis. Br Med J. 1975;1(5950):133and;ndash;7.7. Stenvinkel P, Alvestrand A. Loop diuretic-induced pancreatitis with rechallenge in a patient with malignant hypertension and renal insufficiency. Acta Med Scand. 1988;224(1):89and;ndash;91.8. Call T, Malarkey WB, Thomas FB. Acute pancreatitis secondary to furosemide with associated hyperlipidemia. Am J Dig Dis. 1977;22(9):835and;ndash;43.9. Juang P, Zolty R. Probable loop diuretic-induced pancreatitis in a sulfonamide-allergic patient. Ann Pharmacother. 2006;40(1):128and;ndash;62.10. Badalov N, Baradarian R, Iswara K, Li J, Steinberg W, Tenner S. Drug-induced acute pancreatitis: An evidence-based review. Clin Gastroenterol Hepatol. 2007;5(6):648and;ndash;61.