yemenjmedYemen Journal of MedicinecoVolume 4 Issue 1MultidisciplinaryEnglishJanuary- April 2025NNY20250522ArticleCerebrospinal Fluid Leakage Post-Lumbar Puncture: A Narrative ReviewEnglishY105116ElmukhtarHabas1EnglishNKhaledAlarbi2EnglishYAmnnaRayani3EnglishYAlaHabas4EnglishYEshrakHabas4EnglishYKalifaFarfar5EnglishYAmlHabas6EnglishYAlmehdiErrayes7EnglishYKhawlaAlzaitoni8EnglishYGamalAlfitori7EnglishY10.63475/yjm.v4i1.0074Cerebrospinal fluid (CSF) is critical in maintaining brain interstitial fluid balance and providing hydromechanical protection. Lumbar puncture (LP) is a common invasive procedure for obtaining CSF samples to evaluate central nervous system infections and cancers and measure intracranial pressure. While LP is generally considered safe, it is associated with both minor and major complications. Post-LP meningitis occurs in approximately 50% of spinal anesthesia cases and 9% of diagnostic LPs. Additionally, over 70% of diagnostic LPs result in minor bleeding, which can lead to serious outcomes such as spinal epidural hematoma, nerve damage, or paralysis. Significant consequences of LP include headaches and hearing loss; however, other rare complications, such as cerebral herniation and CSF leak syndrome, must be considered carefully. This review synthesizes findings from multiple studies published in PubMed, Google Scholar, and Scopus, highlighting the need for further research on the complications and interventions related to this commonly performed procedure.EnglishCerebrospinal Fluid (CSF), Lumbar Puncture (LP), Complication of LP, Headache, CSF Leak.https://yemenjmed.com/admin/abstract?id=148References1619and;nbsp;Frederiks J, Koehler P. The first lumbar puncture. Journal of the History of the Neurosciences. 1997;6(2):147-53.Doherty CM, Forbes RB. Diagnostic lumbar puncture. The Ulster medical journal. 2014;83(2):93.Wright BL, Lai JT, Sinclair AJ. 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