yemenjmedYemen Journal of MedicinecoVolume 1 Issue 1MultidisciplinaryEnglishJanuary - June 2022NNY20250327ArticleIs glucose-6-phosphate dehydrogenase deficiency a risk factor for melioidosis?EnglishY4951Almurtada Razok1EnglishNZohaib Yousaf2EnglishYAbdo Lutf3EnglishYMusaedAlsamawi4EnglishY10.32677/yjm.v1i1.3291Melioidosis is an infection that causes high morbidity and mortality. Predisposing risk factors include diabetes mellitus (DM) and immunocompromised state. We report a case of septic shock secondary to bacteremia caused by Burkholderia pseudomallei in a patient who is supposed to be previously healthy and subsequently diagnosed with DM and glucose-6-phosphate dehydrogenase (G6PD) deficiency. He completed 17 days of intravenous antibiotics followed by a 12-week course of oral trimethoprim/sulfamethoxazole. We postulate that G6PD deficiency could be a risk factor for melioidosis.EnglishBurkholderia pseudomallei, Glucose-6-phosphate dehydrogenase deficiency, Hemolysis, Melioidosishttps://yemenjmed.com/admin/abstract?id=17References16191. Cheng AC, Currie BJ. Melioidosis: Epidemiology, pathophysiology, and management. Clin Microbiol Rev 2007;20:533.2. Chowdhury FR, Jilani MS, Barai L, et al. Melioidosis in Bangladesh: A clinical and epidemiological analysis of culture-confirmed cases Trop Med Infect Dis 2018;3:40.3. Melikyan G, Badawi M, Akhtar N, et al. Case of paraspinal collection due to Burkholderia pseudomallei. BMJ Case Rep 2013;2013:bcr2013201447.4. Al Alousi FS, Al Soub H, El-Shafie SS. Subdural empyema due to Burkholderia pseudomallei. Ann Saudi Med 2000;20:272-3.5. Currie BJ, Ward L, Cheng AC. The epidemiology and clinical spectrum of melioidosis: 540 cases from the 20-year Darwin prospective study. PLoS Negl Trop Dis 2010;4:e900.6. Limmathurotsakul D, Kanoksil M, Wuthiekanun V, et al. Activities of daily living associated with acquisition of melioidosis in northeast Thailand: A matched case-control study. PLoS Negl Trop Dis 2013;7:e2072.7. Katz M, Smith S, Conway L, et al. Melioidosis in a patient with Type 1 diabetes mellitus on an insulin pump. Endocrinol Diabetes Metab Case Rep 2018;2018:18-0062.8. Rostami-Far Z, Ghadiri K, Rostami-Far M, et al. Glucose-6-phosphate dehydrogenase deficiency (G6PD) as a risk factor of male neonatal sepsis. J Med Life 2016;9:34-8.