yemenjmedYemen Journal of MedicinecoVolume 4 Issue 3MultidisciplinaryEnglishSeptember- December 2025NNY20251231ArticleChronic Cardiorenal Syndrome: Review: Part 3EnglishY533548ElmukhtarHabas1EnglishNAmlHabas2EnglishYAmnnaRayani3EnglishYAlaHabas4EnglishYKhaledAlarbi5EnglishYEshrakHabas6EnglishYMohamedBaghi5EnglishYMohammadBabikir7EnglishYAbdelrahamanHamad8EnglishYAlmehdiErrayes9EnglishY10.63475/yjm.v4i3.0223heart failure (CHF) induces gradual kidney damage, leading to chronic cardiorenal syndrome (cCRS). This condition is linked with an increase in morbidity and death rate. The commonest cause of cCRS is CHF with a low ejection fraction. CHF causes alteration of hemodynamic variables, such as low cardiac output, neuroendocrine activation, venous congestion, and chronic inflammatory reaction activation. cCRS is a chronic condition that leads to hemodynamic and chronic heart and kidney fibrosis. There are no specific biomarkers to diagnose the cCRS. There is a debate regarding the causal relationship between CHF and kidney function impairment in cCRS. The debate has centered on the efficacy, safety, and costeffectiveness of the currently available therapeutic options, such as diuretics and angiotensinconverting enzyme inhibitors. Full, clear scientific recommendations for the prevention and treatment of cCRS are required.EnglishCardiorenal syndrome type 2, chronic CRS, update in chronic CRS pathophysiology, chronic CRS therapy update, worsening renal function, diuretic resistance, intravenous diuretics, isolated ultrafiltrationhttps://yemenjmed.com/admin/abstract?id=292References1619