yemenjmedYemen Journal of MedicinecoVolume 5 Issue 1MultidisciplinaryEnglishJanuary- April 2026NNY2026045ArticleIntralesional Injections of Vitamin D3 Versus 2% Zinc Sulfate for the Treatment of Palmoplantar Warts: A Comparison of Efficacy and SafetyEnglishY00Abrar ulHaq1EnglishNHiraTariq2EnglishYRameenMasood1EnglishYSehrishAshraf3EnglishYUzmaAmin4EnglishYFariaAsad5EnglishYSaelah Batool6EnglishY10.63475/yjm.v5i1.0279Background: Warts are benign epithelial tumors due to several human papillomavirus strains affecting people of all age groups. Warts give an unappealing look and mostly remain asymptomatic. However, they can become painful, as is the case with palmoplantar warts. For warts, different treatment approaches are available, but all the treatments are very expensive, time-consuming, and painful, and recurrence is very common. This study aimed to compare the efficacy and safety of intralesional injections of vitamin D3 and 2% zinc sulphate solution in the treatment of palmoplantar warts. Methods: In this prospective comparative interventional study (non-randomized trial), done from January 2023 to July 2023, patients with warts from the Outpatient Department of Dermatology of Services Hospital, Lahore, were included. Patients were alternately divided into two groups. Group A patients were given intralesional vitamin D3, while Group B patients were injected with a 2% zinc sulfate solution. Follow-up was done fortnightly for 8 weeks, and then after 12 weeks. Complete response was considered when there was a complete resolution of warts, partial response; if there was >50% and less than 100% reduction in the original width of warts, poor response; if the reduction in the original width of warts wasEnglishSafety, intralesional injection, palmoplantar, vitamin D3, warts, zinc sulfatehttps://yemenjmed.com/admin/abstract?id=349References1619