yemenjmedYemen Journal of MedicinecoVolume 2 Issue 1MultidisciplinaryEnglishJanuary - April 2023 NNY20230510ArticleLong-standing iron deficiency anemia could be a presentation of non-classical celiac disease: A case report and literature reviewEnglishY5457Adnan AbdullahBakarman1EnglishNSamira AwadBanser2EnglishYRasheed MohammedBamekhlah3EnglishY10.32677/yjm.v2i1.3856Celiac disease (CeD) is a complex disorder characterized by gastrointestinal symptoms as well as extraintestinal manifestations, sometimes difficult to diagnose. Commonly referred to as a childhood disease, adult celiac disease is a well-known entity that should be included in the differential diagnosis of chronic diarrhea or malabsorption syndrome. The pathogenesis involves a genetically mediated autoimmune pathway. In individuals with genetic susceptibility, the mucosa of the small intestine is damaged in response to foods containing gluten. The clinical presentation is variable and ranges from typical gastrointestinal symptoms to extra-intestinal and systemic manifestations. Clinical improvement and restoration of the intestinal mucosa occur simply by eliminating gluten from the diet. We reported a case of CeD in a young man after 6 years of iron deficiency anemia (IDA), without asserting a clear etiology during this time. In our country, the search for CeD in patients with IDA is usually forgotten and we hereby put it in the spotlight. EnglishAnemia, Celiac disease, Fatigue, Iron deficiency, Yemenhttps://yemenjmed.com/admin/abstract?id=53References1619Goddard AF, James MW, McIntyre AS, et al. British Society of Gastroenterology. Guidelines for the management of iron deficiency anaemia. Gut 2011;60(10):1309-16.Finberg KE. Iron-refractory iron deficiency anemia. Semin Hematol 2009;46:378-86.Oberhuber G, Granditsch G and Vogelsang H. 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