yemenjmedYemen Journal of MedicinecoVolume 3 Issue 3MultidisciplinaryEnglishSeptember- December 2024NNY20241215ArticleA review on scaffolds: A medical marvelEnglishY175181Shivam DubeyEnglishN10.18231/j.yjom.2024.018The increasing need for organ replacements in an aging society and the loss of tissues and organs due to diseases, accidents, and congenital anomalies are driving the development of new techniques such as three-dimensional bioprinting, precision extrusion deposition, bio-fabrication, elective laser sintering, nanocoating, supramolecular materials, stereolithography, induced pluripotent stem cells, and organoids, fused deposition modelling, electrospinning, and three-dimensional printing for tissue engineering and regenerative medicine. The creation of a wide range of materials, including natural and synthetic polymeric scaffolding materials for therapeutic applications for the repair and regeneration of various deficits and deformities, has been made easier by recent advancements in production techniques and biological materials. EnglishScaffolds, Medicine, Tissue repair, Grafts, Transplantationhttps://yemenjmed.com/admin/abstract?id=6References1619Abdulghani S, Mitchell GR. Biomaterials for in situ tissue regeneration: A review. Biomolecules. 2019;9(11):750.Mabrouk M, Beherei HH, Das DB. Recent Progress in the fabrication techniques of 3D scaffolds for tissue engineering. Mater Sci Eng C. 2020;110:110716.Dzobo K, Turnley T, Wishart A, Rowe A, Kallmeyer K, Van Vollenstee F, et al. Fibroblast-derived extracellular matrix induces chondrogenic differentiation in human adipose-derived mesenchymal stromal/stem cells in vitro. Int J Mol Sci. 2016;17(8):1259.Adel IM, Elmeligy MF, Abdelkhalek AA, Elkasabgy NA. Design and Characterization of highly porous curcumin loaded freeze-dried wafers for wound healing. Eur J Pharm Sci. 2021;164(1):105888.Gaharwar AK, Singh I, Khademhosseini A. Engineered biomaterials for in situ tissue regeneration. Nat Rev Mater. 2020;5:686and;ndash;705.Eltom A, Zhong G, Muhammad A. Scaffold techniques and designs in tissue engineering functions and purposes: A review. Adv Mater Sci Eng. 2019;2019(1):3429527.Sengupta D, Waldman SD, Li S. From in vitro to in situ tissue engineering. Ann Biomed Eng. 2014;42(7):1537and;ndash;45.Elkasabgy NA, Abdel-Salam FS, Mahmoud AA, Basalious EB, Amer MS, Mostafa AA. Long lasting in-situ forming implant loaded with raloxifene HCl: An injectable delivery system for treatment of bone injuries. Int J Pharm. 2019;571:118703.Shi J, Votruba AR, Farokhzad OC, Langer R. Nanotechnology in drug delivery and tissue engineering: From discovery to applications. Nano Lett. 2010;10(9):3223and;ndash;30.Luderer F, Begerow I, Schmidt W, Martin H, Grabow N, Band;uuml;nger CM, et al. Enhanced visualization of biodegradable polymeric vascular scaffolds by incorporation of gold, silver and magnetite nanoparticles. J Biomater Appl. 2012;28(2):219and;ndash;31.Kim JS, Kuk E, Yu KN, Kim JH, Park SJ, Lee HJ, et al. Antimicrobial effects of silver nanoparticles. Nanomed Nanotechnol Biol Med. 2007;3(1):95and;ndash;101.Chen Y, Li N, Yang Y, Liu Y. A Dual targeting cyclodextrin/gold nanoparticle conjugate as a scaffold for solubilization and delivery of paclitaxel. RSC Adv. 2015;5(12):8938and;ndash;41.Suh KS, Lee YS, Seo SH, Kim YS, Choi EM. Gold nanoparticles attenuates antimycin a-induced mitochondrial dysfunction in MC3T3- E1 osteoblastic cells. Biol Trace Elem Res. 2013;153(1-3):428and;ndash;36.Ravichandran R, Sridhar R, Venugopal JR, Sundarrajan S, Mukherjee S, Ramakrishna S. Gold nanoparticle loaded hybrid nanofibers for cardiogenic differentiation of stem cells for infarcted myocardium regeneration. Macromol Biosci. 2014;14(4):515and;ndash;25.Fathi-Achachelouei M, Knopf-Marques H, Silva CD, Barthand;egrave;s J, Bat E, Tezcaner A. Use of nanoparticles in tissue engineering and regenerative medicine. Front Bioeng Biotechnol. 2019;7:113.