Impact of Preoperative Baseline Serum Urea and Creatinine Levels Among Patients with Perforated Peptic Ulcer Disease in Lafia, North Central Nigeria

Horace Ojobo Agada1, Joseph Taruni Godwin2, Lazarus Babangida Adokwe2

Keywords: Peptic ulcer disease, perforation, serum creatinine, serum urea, morta

DOI: 0.63475/yjm.v4i2.0204

DOI URL: https://doi.org/0.63475/yjm.v4i2.0204

Publish Date: 22-09-2025

Download PDF

Pages: 435 - 442

Downloads: 1

Citation: 0

Author Affiliation:

1 Consultant, Department of surgery Federal University Teaching Hospital Lafia Nasarawa state, Nigeria
2 Registrar, Department of surgery, Dalhatu Araf Specialist Hospital, Lafia, Nasarawa state, Nigeria

Abstract

Background: Perforation is the most serious surgical complication of peptic ulcer disease due to its attendant high morbidity and mortality. Hypovolemia, a consequence of gastro-duodenal perforation, is considered to be a cause of renal hypo perfusion with accompanied decreased clearance of urea and creatinine. The aim of this study was to determine the preoperative baseline serum urea and creatinine profile among patients with perforated peptic ulcer disease and the relationship of serum urea and creatinine with the outcome of care.

Methods: A retrospective study of patients who had operation for perforated peptic ulcer disease over a 5-year period at Dalhatu Araf Specialist Hospital, lafia, North-central Nigeria was conducted.

Results: Sixty-four patients were studied with a mean age of 36.6 ± 12.3 years. Majority of the patients were males, 59 (92.2%). While 38 (59.3%) patients had elevated preoperative baseline urea levels, 37 (57.8%) patients had elevated creatinine levels. Out of 29 patients who had surgical site infection, 16 (55.2%) had elevated serum urea (p = 0.535) while 19 (65.2 %) had elevated serum creatinine (p = 0.579). An overall in-hospital mortality rate of 14.1% was recorded. There was statistically significant relationship between elevated serum urea and inhospital mortality (p = 0.007).

Conclusion: This result showed that preoperative baseline serum urea and creatinine levels were elevated in majority of the patients. In addition, the result of this study suggests that elevated baseline serum urea level has considerable relationship with in-hospital mortality

---