A Rare Case of Alobar Holoprosencephaly With Cyclopia in a Male Neonate

Adegoriola Olubisi Ojurongbe¹, Uche Augustine Akunaeziri¹, Victoria Fom¹, Abdulsalam Uthman¹, Tivkaa Terna David¹, Fijabiyi Matthew Olusegun², Paul Chukwudi Mocha¹, Emmanuel Chinedu Nnadi¹

Keywords: Cyclopia, neonate, alobar holoprosencephaly, male, rare, congenital

DOI: 10.63475/yjm.v4i3.0144

DOI URL: https://doi.org/10.63475/yjm.v4i3.0144

Publish Date: 31-12-2025

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Pages: 637 - 639

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Author Affiliation:

1 Consultant, Department of Obstetrics and Gynaecology, Federal Medical Centre, Keffi, Nasarawa State, Nigeria
2 Consultant, Department of Obstetrics and Gynaecology, Ladoke Akintola University Teaching Hospital, Ogbomosho, Oyo State, Nigeria

Abstract

Cyclopia is a rare congenital anomaly characterized by a single eye in the middle of the forehead, among other features. This anomaly is usually not compatible with life. It is a serious median facio-cerebral developmental deformity in which the baby is stillborn or dies soon after birth. We present the case of a woman aged 38 years (primigravida) referred to us at 33 weeks of pregnancy and delivered a male macerated stillborn weighing 2.8 kg. The baby had a single central eye, low-set ears, and a proboscis above the eye. The patient was said to have been on a weightloss supplement, which was discontinued after the confirmation of pregnancy by ultrasound at 6 weeks of gestation. This case report underscores the need for more public enlightenment on the adverse effects of drugs on pregnancy, preconception clinic, regular antenatal visit, and mandatory anomaly scan as part of our routine investigations for at-risk patients, as this will help in early diagnosis and treatment of congenital anomalies.

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