A review on scaffolds: A medical marvel

Shivam Dubey

Author Affiliation

Rani Durgavati Vishwavidyalaya, Jabalpur, Madhya Pradesh, India

Abstract

The increasing need for organ replacements in an aging society and the loss of tissues and organs due to diseases, accidents, and congenital anomalies are driving the development of new techniques such as three-dimensional bioprinting, precision extrusion deposition, bio-fabrication, elective laser sintering, nanocoating, supramolecular materials, stereolithography, induced pluripotent stem cells, and organoids, fused deposition modelling, electrospinning, and three-dimensional printing for tissue engineering and regenerative medicine. The creation of a wide range of materials, including natural and synthetic polymeric scaffolding materials for therapeutic applications for the repair and regeneration of various deficits and deformities, has been made easier by recent advancements in production techniques and biological materials. 

DOI: 10.63475/j.yjom.2024.018

Keywords: Scaffolds, Medicine, Tissue repair, Grafts, Transplantation

Pages: 175-181

View: 59

Download: 53

DOI URL: https://doi.org/10.63475/j.yjom.2024.018

Publish Date: 15-12-2024

Full Text

The ability of living things to repair damaged tissue on their own is crucial to their existence. Any change to a tissue’s structure, whether it be soft or rigid, is referred to as tissue damage. Living tissue is a complex, three-dimensional entity. Bones and teeth are examples of hard tissues, whereas ligaments, muscles, and tendons are examples of soft tissues. Soft tissues are any tissues that link and support various bodily organs and structures. Chemical, mechanical, or even pathogenic factors may cause tissue injury. Our bodies are designed to start a self-healing process called tissue regeneration to repair tissue damage. However, tissue/organ transplantation is the only option when the damage is so great that the body’s self-healing system cannot keep up with the pace of cellular death or when the tissue is non-replicating. To put it another way, scaffolds are made to resemble the extracellular matrix and help the body heal itself when self-healing isn’t enough.

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